The results of concomitant use or discontinuation of cytochrome P450 3A4 inducers, 3A4 inhibitors, or 2D6 inhibitors with codeine are advanced, necessitating mindful thought of the results around the dad or mum drug, codeine, as well as active metabolite, morphine.
This medication may perhaps interfere with specified lab checks (including some pregnancy tests, blood sugar assessments, amylase/lipase concentrations), perhaps causing false check success. Ensure lab personnel and all your Physicians know you use this drug.
Subsequent oral administration or topical software of phenylephrine on the mucosa, constriction of blood vessels within the nasal mucosa relieves nasal congestion affiliated with allergy or head colds. Adhering to oral administration, nasal decongestion may well arise within fifteen or 20 minutes and should persist for nearly four several hours.
Codeine Codeine is an opioid agonist comparatively selective to the mu-opioid receptor, but with a much weaker affinity than morphine. The analgesic and antitussive Qualities of codeine are speculated to originate from its conversion to morphine.
Due to likely for promethazine to reverse epinephrine’s vasopressor impact, epinephrine really should not be employed to take care of hypotension connected with promethazine overdose.
Report any Unwanted effects from codeine- or tramadol- made up of medicines to your health treatment Skilled and the FDA MedWatch system, working with the data from the “Make contact with FDA” box at The underside of the webpage.
Prevent the use of Promethazine VC with Codeine Oral Remedy in people getting muscle mass relaxants. If concomitant use is essential, keep track of sufferers for signs of respiratory depression Which may be larger than otherwise expected.
Promethazine with Codeine Oral Solution contains promethazine, a phenothiazine. Phenothiazines are involved with dystonic reactions, specially in pediatric people who have an acute illness connected with dehydration.
In case you have an allergy to codeine, promethazine, or every other Portion of promethazine and codeine. When you are allergic to promethazine and codeine; any Section of promethazine and codeine; or any other medicine, foods, or substances. Explain to your medical doctor in regards to the allergy and what symptoms you had. When you have any of those health problems: Lung or respiratory complications like asthma, issues respiration, or sleep apnea; higher levels of carbon dioxide inside the blood; or belly or bowel block or narrowing. When you have taken sure medicines for melancholy or Parkinson's disorder in the last 14 times. This contains isocarboxazid, phenelzine, tranylcypromine, selegiline, or rasagiline. Quite high blood pressure could take place. If you're getting any of these medication: Linezolid or methylene blue.
All medicines may perhaps result in Unwanted side effects. Even so, Lots of people don't have any Unwanted effects or have only small Uncomfortable side effects. Call your medical professional or get health-related assistance if any of these side effects or any other Unwanted side effects hassle you or tend not to disappear: Emotion sleepy. Dizziness. Emotion anxious and excitable. Constipation.
Ahead of taking this medication, convey to your doctor or pharmacist In case you are allergic to any of its substances; or to opioid pain relievers (such as morphine); or Should you have any other allergy symptoms.
Carcinogenicity experiments have been conducted with promethazine hydrochloride. Two-12 months studies in F344/N rats and B6C3F1 mice ended up conducted to evaluate the carcinogenic possible of promethazine hydrochloride. No proof of tumorigenicity was observed in male and feminine rats at promethazine hydrochloride oral doses up to 33 mg/kg/day for five times/week (about comparable to 10 situations the MRHD on the mg/m2 foundation).
Employ other supportive actions (including oxygen and vasopressors) while in the administration of circulatory shock and pulmonary edema as indicated. Cardiac arrest or arrhythmias will require State-of-the-art lifestyle-guidance methods. Gastric emptying could possibly be useful in taking away unabsorbed drug.
Endocrine/Metabolic: Situations more info of serotonin syndrome, a probably lifestyle-threatening issue, are actually noted in the course of concomitant use of opioids with serotonergic medicines.